Structure of PDB 2z28 Chain B Binding Site BS02

Receptor Information
>2z28 Chain B (length=335) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVE
AAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKL
YPAGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVM
EPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHML
VGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKES
SCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTF
IELVREEQQVAESIALTDDTLVPFLAGETVRWSVK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2z28 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2z28 Kinetic and Structural Analysis of Mutant Escherichia coli Dihydroorotases: A Flexible Loop Stabilizes the Transition State
Resolution1.87 Å
Binding residue
(original residue number in PDB)		K102 H139 H177
Binding residue
(residue number reindexed from 1)		K99 H128 H166
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H16 H18 K102 H139 H177 D250
Catalytic site (residue number reindexed from 1) H13 H15 K99 H128 H166 D239
Enzyme Commision number 3.5.2.3: dihydroorotase.
Gene Ontology
Molecular Function
GO:0004151 dihydroorotase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2z28, PDBe:2z28, PDBj:2z28
PDBsum2z28
PubMed17711307
UniProtP05020|PYRC_ECOLI Dihydroorotase (Gene Name=pyrC)

[Back to BioLiP]