Structure of PDB 2wvk Chain B Binding Site BS02

Receptor Information
>2wvk Chain B (length=382) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRLEIPNHTERFGVVRLHEVQRILELDSGRVRDESPAVGLRRLDDADLRD
VLEQTAIVVPTRNERLKLLEGVLSGIPHEALILVASNSSPDRFQMERDLL
EEFAHLTERPALIFHQKDPALAEALRAGGYPHPIGEDGLVRSGKAEGMIL
ALVFAALSGRRYVGFIDADNYFPGAVWEYVRAYAAGFLMAKTPFAMVRIL
WRGVVFRRYGRVSERNNRALNQLIGGVSGFETDVVKTANAGEHAMSLGLA
LRLPLASGYAVEPQELVSLLELYGGVFPLEDEEVLQHGVEIFQIETRNPH
LHENKGDEHIRDMLLACLATVYHSKLATEEVRQSVLEELQAAGALAPGEE
PPPPVLYPPLSSLDLQAVRKALRGHFSRFRVP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2wvk Chain B Residue 1393 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2wvk Structural Analysis of Thermus Thermophilus Hb27 Mannosyl-3-Phosphoglycerate Synthase Provides Evidence for a Second Catalytic Metal Ion and New Insight Into the Retaining Mechanism of Glycosyltransferases.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		E251 H309 H311
Binding residue
(residue number reindexed from 1)		E242 H300 H302
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0050504 mannosyl-3-phosphoglycerate synthase activity
Biological Process
GO:0051479 mannosylglycerate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wvk, PDBe:2wvk, PDBj:2wvk
PDBsum2wvk
PubMed20356840
UniProtQ72K30

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