Structure of PDB 2w7p Chain B Binding Site BS02

Receptor Information
>2w7p Chain B (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKA
QLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGS
MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK
EILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFINSVVFGTSA
QEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQ
AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSET
SWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCS
ELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKE
LLKTEIDADFPHPLRLRLMGVRISSFPNEE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2w7p Structural and Functional Elucidation of the Mechanism Promoting Error-Prone Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-Oxo-2'-Deoxyguanosine Adduct.
Resolution3.71 Å
Binding residue
(original residue number in PDB)		T44 F49 R63 M135 P153 F155 I156 S388 S391 R413 K414 S415 M416 S417 V418 E419 R420 T421 R507
Binding residue
(residue number reindexed from 1)		T12 F17 R31 M103 P121 F123 I124 S298 S301 R323 K324 S325 M326 S327 V328 E329 R330 T331 R417
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2w7p, PDBe:2w7p, PDBj:2w7p
PDBsum2w7p
PubMed19542228
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

[Back to BioLiP]