Structure of PDB 2w7o Chain B Binding Site BS02

Receptor Information
>2w7o Chain B (length=429) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKA
QLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGS
MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK
EILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFINSVVFGTSA
QEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQ
AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSET
SWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCS
ELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKE
LLKTEIDADFPHPLRLRLMGVRISSFPNE
Ligand information
Receptor-Ligand Complex Structure
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PDB2w7o Structural and Functional Elucidation of the Mechanism Promoting Error-Prone Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-Oxo-2'-Deoxyguanosine Adduct.
Resolution3.16 Å
Binding residue
(original residue number in PDB)		T44 F49 R63 M133 M135 P153 F155 S388 S391 K414 M416 S417 V418 E419 R420 T421 R507
Binding residue
(residue number reindexed from 1)		T12 F17 R31 M101 M103 P121 F123 S298 S301 K324 M326 S327 V328 E329 R330 T331 R417
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2w7o, PDBe:2w7o, PDBj:2w7o
PDBsum2w7o
PubMed19542228
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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