Structure of PDB 2vd3 Chain B Binding Site BS02

Receptor Information

>2vd3 Chain B (length=288) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H)

AVPKIRIAVPSKGRISEPAIRLLENAGVGLKDTVRKLFSKTQHPQIEVMF
SRAADIPEFVADGAADLGITGYDLIVERGSDVEILEDLKYGRASLVLAAP
EDSTIRGPEDIPRGAVIATEFPGITENYLREHGIDAEVVELTGSTEIAPF
IGVADLITDLSSTGTTLRMNHLRVIDTILESSVKLIANRESYATKSGIIE
ELRTGIRGVIDAEGKRLVMLNIDRKNLDRVRALMPGMTGPTVSEVLSDNG
VVAVHAVVDEKEVFNLINRLKAVGARDILVVPIERIIP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2vd3 Chain B Residue 1293

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2vd3 The Structure of Histidine Inhibited Hisg from Methanobacterium Thermoautotrophicum
• Resolution: 2.45 Å
• Binding residue (original residue number in PDB): K10 R51 A52
• Binding residue (residue number reindexed from 1): K12 R52 A53
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.2.17: ATP phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003879 ATP phosphoribosyltransferase activity
• GO:0005524 ATP binding
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000105 L-histidine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2vd3, PDBe:2vd3, PDBj:2vd3
• PDBsum: 2vd3
• UniProt: O27550|HIS1_METTH ATP phosphoribosyltransferase (Gene Name=hisG)