Structure of PDB 2uuj Chain B Binding Site BS02
Receptor Information
>2uuj Chain B (length=252) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
Ligand information
>2uuj Chain H (length=10) Species:
6421
(Hirudo medicinalis) [
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DFEEIPEEYL
Receptor-Ligand Complex Structure
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PDB
2uuj
The Determination of Protonation States in Proteins.
Resolution
1.32 Å
Binding residue
(original residue number in PDB)
F34 L65 R67 R73 T74 R75 Y76 K81 I82
Binding residue
(residue number reindexed from 1)
F19 L60 R62 R68 T69 R70 Y71 K77 I78
Enzymatic activity
Catalytic site (original residue number in PDB)
H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)
H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:2uuj
,
PDBe:2uuj
,
PDBj:2uuj
PDBsum
2uuj
PubMed
17642517
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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