Structure of PDB 2r8k Chain B Binding Site BS02

Receptor Information
>2r8k Chain B (length=511) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRMSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSKE
DPVVCVQWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKKG
EDFWQYHDGCGSWVQDPAKQISVEDHKVSLEPYRRESRKALKIFKSACDL
VERASIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGGN
YDINSHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILALGSQVCKGI
RDSIKDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDCG
KFEITSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLDA
KVKQSDYDRSTSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSN
KNLRGKSCNSIVDCISWLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLK
TKSYEVYRKSGPVAYKGINFQSHELLKVGIKFVTDLDIKGKNKSYYPLTK
LSMTITNFDII
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2r8k Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Q55 S58 K125 K393 S394 M395 M396 S397 N398 R426
Binding residue
(residue number reindexed from 1)		Q57 S60 K127 K395 S396 M397 M398 S399 N400 R428
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2r8k, PDBe:2r8k, PDBj:2r8k
PDBsum2r8k
PubMed17991862
UniProtQ04049|POLH_YEAST DNA polymerase eta (Gene Name=RAD30)

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