Structure of PDB 2p5b Chain B Binding Site BS02
Receptor Information
>2p5b Chain B (length=337) Species:
9606
(Homo sapiens) [
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PSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASY
DDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTP
RYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDL
VEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWY
SVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDK
VTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCR
KDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLP
Ligand information
>2p5b Chain J (length=14) Species:
6431
(Urechis caupo) [
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KSAPATGGVKKPHR
Receptor-Ligand Complex Structure
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PDB
2p5b
Structural basis of the recognition of a methylated histone tail by JMJD2A.
Resolution
1.99 Å
Binding residue
(original residue number in PDB)
I71 N86 A134 D135 I166 I168 E169 G170 Y175 Y177 M242 S288 N290 V313 K314 I315 S316
Binding residue
(residue number reindexed from 1)
I62 N77 A125 D126 I157 I159 E160 G161 Y166 Y168 M233 S279 N281 V304 K305 I306 S307
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G161 Y168 H179 E181 H267 S279
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:2p5b
,
PDBe:2p5b
,
PDBj:2p5b
PDBsum
2p5b
PubMed
17567753
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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