Structure of PDB 2oz0 Chain B Binding Site BS02

Receptor Information
>2oz0 Chain B (length=396) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APGETKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAYYSSG
ANDEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSAT
ALCKLGNPLEGEKDVARGCGQGVTKVPQMISTLASCSPEEIIEAAPSDKQ
IQWYQLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKF
SNGASRALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIG
VSGVVLSNQGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRR
GTDVLKALCLGAKGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRL
LGVTSIAELKPDLLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFED
Ligand information
Ligand IDPYR
InChIInChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
InChIKeyLCTONWCANYUPML-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CC(=O)C(O)=O
OpenEye OEToolkits 1.7.6CC(=O)C(=O)O
ACDLabs 12.01O=C(C(=O)O)C
FormulaC3 H4 O3
NamePYRUVIC ACID
ChEMBLCHEMBL1162144
DrugBankDB00119
ZINCZINC000001532517
PDB chain2oz0 Chain B Residue 571 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2oz0 Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y143 Y254 Q373 R376
Binding residue
(residue number reindexed from 1)		Y46 Y157 Q259 R262
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) S228 Y254 T280 D282 K349 Q373
Catalytic site (residue number reindexed from 1) S131 Y157 T183 D185 K235 Q259
Enzyme Commision number 1.1.2.3: L-lactate dehydrogenase (cytochrome).
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:2oz0, PDBe:2oz0, PDBj:2oz0
PDBsum2oz0
PubMed17563122
UniProtP00175|CYB2_YEAST L-lactate dehydrogenase (cytochrome) (Gene Name=CYB2)

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