Structure of PDB 2o8c Chain B Binding Site BS02

Receptor Information

>2o8c Chain B (length=932) Species: 9606 (Homo sapiens)

PTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMR
KWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGF
PEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRR
EICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSHTRAYGVCFVD
TSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSS
LSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIVMLPQVLKGMT
SESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLD
SDTVSKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKR
LLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLL
SKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKII
GIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKAR
KTGLITPKAGFSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIG
RNRYQLEIPENFTTRNLPEYELKSTKKGCKRYWTKTIEKKLANLINAEER
RDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPM
CRPVILLPEDTPPFLELKGSRHPCGDDFIPNDILIGCEEEEQENKAYCVL
VTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGSTF
FVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIK
CRTLFSTHYHSLVEDYSQNVAVRLGHMACMTFLYKFIKGACPKSYGFNAA
RLANLPEEVIQKGHRKAREFEKMNQSLRLFRE

Ligand information

>2o8c Chain F (length=15)

cctagcgtgcggttc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2o8c Structure of the Human MutSalpha DNA Lesion Recognition Complex.
• Resolution: 3.37 Å
• Binding residue (original residue number in PDB): F432 E434 L449 V450 M452 K453 G460 P462 R468 Y469 W970 I972 T999 K1000 K1004
• Binding residue (residue number reindexed from 1): F71 E73 L88 V89 M91 K92 G99 P101 R107 Y108 W597 I599 T625 K626 K630

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0030983 mismatched DNA binding
• GO:0140664 ATP-dependent DNA damage sensor activity

Biological Process

• GO:0006298 mismatch repair

External links

• PDB: RCSB:2o8c, PDBe:2o8c, PDBj:2o8c
• PDBsum: 2o8c
• PubMed: 17531815
• UniProt: P52701|MSH6_HUMAN DNA mismatch repair protein Msh6 (Gene Name=MSH6)