Structure of PDB 2o8b Chain B Binding Site BS02

Receptor Information
>2o8b Chain B (length=930) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMR
KWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGF
PEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRR
EICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSHTRAYGVCFVD
TSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSS
LSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIVMLPQVLKGMT
SESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLD
SDTVSKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKR
LLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLL
SKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKII
GIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKAR
KTGLITPKAGFSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIG
RNRYQLEIPENFTTRNLPEYELKSTKKGCKRYWTKTIEKKLANLINAEER
RDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPM
CRPVILLPEDTPPFLELKGSRHPCGDDFIPNDILIGCEEEEQKAYCVLVT
GPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGSTFFV
ELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCR
TLFSTHYHSLVEDYSQNVAVRLGHMACMTFLYKFIKGACPKSYGFNAARL
ANLPEEVIQKGHRKAREFEKMNQSLRLFRE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2o8b Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		F432 E434 L449 V450 M452 K453 G460 P462 R468 Y469 W970 T999 K1000 K1004
Binding residue
(residue number reindexed from 1)		F71 E73 L88 V89 M91 K92 G99 P101 R107 Y108 W597 T625 K626 K630
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2o8b, PDBe:2o8b, PDBj:2o8b
PDBsum2o8b
PubMed17531815
UniProtP52701|MSH6_HUMAN DNA mismatch repair protein Msh6 (Gene Name=MSH6)

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