Structure of PDB 2o06 Chain B Binding Site BS02

Receptor Information
>2o06 Chain B (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVL
VLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVK
HPSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQN
QDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLH
LDLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPV
QPLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALNDVS
Ligand information
Ligand IDPUT
InChIInChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2
InChIKeyKIDHWZJUCRJVML-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CCN)CN
ACDLabs 10.04
CACTVS 3.341		NCCCCN
FormulaC4 H12 N2
Name1,4-DIAMINOBUTANE;
PUTRESCINE
ChEMBLCHEMBL46257
DrugBankDB01917
ZINCZINC000005828633
PDB chain2o06 Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2o06 Structure and mechanism of spermidine synthases.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S174 D176 Y241
Binding residue
(residue number reindexed from 1)		S161 D163 Y228
Annotation score5
Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0008295 spermidine biosynthetic process
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o06, PDBe:2o06, PDBj:2o06
PDBsum2o06
PubMed17585781
UniProtP19623|SPEE_HUMAN Spermidine synthase (Gene Name=SRM)

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