Structure of PDB 2nqa Chain B Binding Site BS02

Receptor Information
>2nqa Chain B (length=318) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGPQTQGI
IWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYR
VVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQG
NEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGSEFYDLKKPPANL
YQIIRKALCAGSLLGCSIDVYSAAEAEAITSQKLVKSHAYSVTGVEEVNF
QGHPEKLIRLRNPWGEEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFW
MSLSDFVRQFSRLEICNL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2nqa Structure of Human Calpain 8
Resolution2.2 Å
Binding residue
(original residue number in PDB)		G103 C105 G197 S261
Binding residue
(residue number reindexed from 1)		G80 C82 G174 S237
Enzymatic activity
Catalytic site (original residue number in PDB) Q99 C105 H262 N286 W288
Catalytic site (residue number reindexed from 1) Q76 C82 H238 N262 W264
Enzyme Commision number 3.4.22.53: calpain-2.
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2nqa, PDBe:2nqa, PDBj:2nqa
PDBsum2nqa
PubMed
UniProtA6NHC0|CAN8_HUMAN Calpain-8 (Gene Name=CAPN8)

[Back to BioLiP]