Structure of PDB 2nph Chain B Binding Site BS02

Receptor Information
>2nph Chain B (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNF
Ligand information
Receptor-Ligand Complex Structure
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PDB2nph Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates
Resolution1.65 Å
Binding residue
(original residue number in PDB)		G1027 A1028 D1029 M1046 G1048 F1053
Binding residue
(residue number reindexed from 1)		G27 A28 D29 M46 G48 F53
Enzymatic activity
Catalytic site (original residue number in PDB) D1025 T1026 G1027
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2nph, PDBe:2nph, PDBj:2nph
PDBsum2nph
PubMed17116869
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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