Structure of PDB 2ht9 Chain B Binding Site BS02

Receptor Information

>2ht9 Chain B (length=111) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TAPVNQIQETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLE
YGNQFQDALYKMTGERTVPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQC
YLKKSKRKEFQ

Ligand information

InChI=1S/2Fe.2S

NIXDOXVAJZFRNF-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04	[Fe]1S[Fe]S1
CACTVS 3.341 OpenEye OEToolkits 1.5.0	S1[Fe]S[Fe]1

Formula

Fe2 S2

Name

FE2/S2 (INORGANIC) CLUSTER

PDB chain

2ht9 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2ht9 Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria
Resolution	1.9 Å
Binding residue (original residue number in PDB)	C37 S38 Y39
Binding residue (residue number reindexed from 1)	C24 S25 Y26
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:2ht9, PDBe:2ht9, PDBj:2ht9
PDBsum	2ht9
PubMed	17121859
UniProt	Q9NS18\|GLRX2_HUMAN Glutaredoxin-2, mitochondrial (Gene Name=GLRX2)

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