Structure of PDB 2gig Chain B Binding Site BS02

Receptor Information
>2gig Chain B (length=240) Species: 727 (Haemophilus influenzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFIKPIYQDINSILIGQKVFEKLVYKFLKENLSDLTFKQYEYLNDLFMKN
PAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILL
VKDQFYELLDVKTRNISKSAFAPNIISAYKLAQTCAKMIDNKEFDLFDIN
YLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQ
GFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2gig Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
Resolution1.83 Å
Binding residue
(original residue number in PDB)		G92 K93 F138 Y199 N201 A203 A204 R241 K248
Binding residue
(residue number reindexed from 1)		G75 K76 F121 Y182 N184 A186 A187 R224 K231
Binding affinityPDBbind-CN: Kd=1.03nM
Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
Biological Process
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:2gig, PDBe:2gig, PDBj:2gig
PDBsum2gig
PubMed16675462
UniProtP17743|T2C2_HAEIF Type II restriction enzyme HincII (Gene Name=hincIIR)

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