Structure of PDB 2g09 Chain B Binding Site BS02

Receptor Information

>2g09 Chain B (length=291) Species: 10090 (Mus musculus)

AVHLKMMPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSR
FSYNGKRCPTCHNIIDNCKLVTDECRRKLLQLKEQYYAIEVDPVLTVEEK
FPYMVEWYTKSHGLLIEQGIPKAKLKEIVADSDVMLKEGYENFFGKLQQH
GIPVFIFSAGIGDVLEEVIRQAGVYHSNVKVVSNFMDFDENGVLKGFKGE
LIHVFNKHDGALKNTDYFSQLKDNSNIILLGDSQGDLRMADGVANVEHIL
KIGYLNDRVDELLEKYMDSYDIVLVKEESLEVVNSILQKTL

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 2g09 Chain B Residue 904

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2g09 Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): F50 D51 S164 A165 K213
• Binding residue (residue number reindexed from 1): F44 D45 S158 A159 K207
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.5: 5'-nucleotidase.
  3.1.3.91: 7-methylguanosine nucleotidase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0008253 5'-nucleotidase activity

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2g09, PDBe:2g09, PDBj:2g09
• PDBsum: 2g09
• PubMed: 16672222
• UniProt: Q9D020|5NT3A_MOUSE Cytosolic 5'-nucleotidase 3A (Gene Name=Nt5c3a)