Structure of PDB 2cua Chain B Binding Site BS02

Receptor Information

>2cua Chain B (length=132) Species: 274 (Thermus thermophilus)

AYTLATHTAGAGKLERVDPTTVRQEGPWADPAQAVVQTGPNQYTVYVLAF
AFGYQPNPIEVPQGAEIVFKITSPDVIHGFHVEGTNINVEVLPGEVSTVR
YTFKRPGEYRIICNQYCGLGHQNMFGTIVVKE

Ligand information

• Ligand ID: CUA
• InChI: InChI=1S/2Cu
• InChIKey: ALKZAGKDWUSJED-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Cu][Cu]
• Formula: Cu2
• Name: DINUCLEAR COPPER ION
• PDB chain: 2cua Chain B Residue 170

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2cua The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6 A resolution.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): H114 C149 Q151 C153 H157 M160
• Binding residue (residue number reindexed from 1): H78 C113 Q115 C117 H121 M124
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): F86 F88
• Catalytic site (residue number reindexed from 1): F50 F52
• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:2cua, PDBe:2cua, PDBj:2cua
• PDBsum: 2cua
• PubMed: 10360350
• UniProt: P98052|COX2_THETH Cytochrome c oxidase subunit 2 (Fragment) (Gene Name=cbaB)