Structure of PDB 2atl Chain B Binding Site BS02

Receptor Information

>2atl Chain B (length=341) Species: 2287 (Saccharolobus solfataricus)

GIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEA
RKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIE
IASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVF
AKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN
KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVT
MKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGR
TFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI

Ligand information

>2atl Chain J (length=19)

ctaacgctaccatccaacc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2atl Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): V1032 R1036 F1037 S1040 G1041 A1042 E1219 A1220 R1242 K1243 S1244 R1247 I1248 T1250 R1331 R1332 R1336
• Binding residue (residue number reindexed from 1): V32 R36 F37 S40 G41 A42 E219 A220 R242 K243 S244 R247 I248 T250 R331 R332 R336

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2atl, PDBe:2atl, PDBj:2atl
• PDBsum: 2atl
• PubMed: 16379496
• UniProt: Q97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)