Structure of PDB 2al2 Chain B Binding Site BS02

Receptor Information
>2al2 Chain B (length=430) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGATGVHEALEMRDG
DKSKWMGKGVLHAVKNVNDVIAPAFVKADIDVKDQKAVDDFLISLDGTAN
KSKLGANAILGVSLAASRAAAAEKDVPLYKHLADLSKSKTSPYVLPVPFL
NVLNGGALALQEFMIAPTGAKTFAEALRIGSEVYHNLKSLTKKRYGASAG
NVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKVKIGLDCASSEFFKDG
KYDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYPIVSIEDPFAEDDWEAW
SHFFKTAGIQIVADDLTVTNPKRIATAIEKKAADALLLKVNQIGTLSESI
KAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAPARSERL
AKLNQLLRIEEELGDNAVFAGENFHHGDKL
Ligand information
Ligand IDPEP
InChIInChI=1S/C3H5O6P/c1-2(3(4)5)9-10(6,7)8/h1H2,(H,4,5)(H2,6,7,8)
InChIKeyDTBNBXWJWCWCIK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C=C(C(=O)O)OP(=O)(O)O
CACTVS 3.341OC(=O)C(=C)O[P](O)(O)=O
ACDLabs 10.04O=C(O)C(\OP(=O)(O)O)=C
FormulaC3 H5 O6 P
NamePHOSPHOENOLPYRUVATE
ChEMBLCHEMBL1235228
DrugBankDB01819
ZINCZINC000003870145
PDB chain2al2 Chain B Residue 440 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2al2 Structure and catalytic properties of an engineered heterodimer of enolase composed of one active and one inactive subunit
Resolution1.85 Å
Binding residue
(original residue number in PDB)		G37 A38 D246 D320 K345 R374 S375 K396
Binding residue
(residue number reindexed from 1)		G37 A38 D240 D314 K339 R368 S369 K390
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) E168 E211 D246 E295 D320 K345 H373 K396
Catalytic site (residue number reindexed from 1) E162 E205 D240 E289 D314 K339 H367 K390
Enzyme Commision number 4.2.1.11: phosphopyruvate hydratase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:1904408 melatonin binding
Biological Process
GO:0006096 glycolytic process
GO:0032889 regulation of vacuole fusion, non-autophagic
Cellular Component
GO:0000015 phosphopyruvate hydratase complex
GO:0000324 fungal-type vacuole
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2al2, PDBe:2al2, PDBj:2al2
PDBsum2al2
PubMed16309698
UniProtP00924|ENO1_YEAST Enolase 1 (Gene Name=ENO1)

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