Structure of PDB 1zz7 Chain B Binding Site BS02

Receptor Information
>1zz7 Chain B (length=174) Species: 43759 (Streptomyces wedmorensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTGFAELLKDRREQVKMDHAALASLLGETPETVAAWENGEGGELTLTQL
GRIAHVLGTSIGALTPPAGNDLDDGVIIQMPYVYNCLVRTKRAPSLVPLV
VDVLTDNPDDAKFNSGHAGNEFLFVLEGEIHMKWGNPKEALLPTGASMFV
EEHVPHAFTAAKGTGSAKLIAVNF
Ligand information
Ligand IDS0H
InChIInChI=1S/C3H9O4P/c1-3(4)2-8(5,6)7/h3-4H,2H2,1H3,(H2,5,6,7)/t3-/m0/s1
InChIKeyZFVCONUOLQASEW-VKHMYHEASA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[CH](O)C[P](O)(O)=O
CACTVS 3.341C[C@H](O)C[P](O)(O)=O
OpenEye OEToolkits 1.5.0CC(CP(=O)(O)O)O
OpenEye OEToolkits 1.5.0C[C@@H](CP(=O)(O)O)O
ACDLabs 10.04O=P(O)(O)CC(O)C
FormulaC3 H9 O4 P
Name(S)-2-HYDROXYPROPYLPHOSPHONIC ACID
ChEMBL
DrugBank
ZINC
PDB chain1zz7 Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zz7 Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Resolution2.1 Å
Binding residue
(original residue number in PDB)		N135 H138 E142 H180 F182
Binding residue
(residue number reindexed from 1)		N114 H117 E121 H156 F158
Annotation score5
Enzymatic activity
Enzyme Commision number 1.11.1.23: (S)-2-hydroxypropylphosphonic acid epoxidase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008198 ferrous iron binding
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0051289 protein homotetramerization
GO:1901766 phosphinothricin biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zz7, PDBe:1zz7, PDBj:1zz7
PDBsum1zz7
PubMed16015285
UniProtQ56185|HPPE_STRWE (S)-2-hydroxypropylphosphonic acid epoxidase (Gene Name=hppE)

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