Structure of PDB 1zab Chain B Binding Site BS02

Receptor Information
>1zab Chain B (length=134) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEPEHVQRLLLSSREAKKSAYCPYSRFPVGAALLTGDGRIFSGCNIENAC
YPLGVCAERTAIQKAISEGYKDFRAIAISSDLQEEFISPCGACRQVMREF
GTDWAVYMTKPDGTFVVRTVQELLPASFGPEDLQ
Ligand information
Ligand IDURD
InChIInChI=1S/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-2,6,8-10,12,15-16H,3-4H2/t6-,8-,9-,10-/m1/s1
InChIKeyWIRVQQCUKDPURA-PEBGCTIMSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1C(=O)C=CN(C1=O)C2C(C(C(O2)CO)O)O
OpenEye OEToolkits 1.5.0C1C(=O)C=CN(C1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
ACDLabs 10.04O=C1C=CN(C(=O)C1)C2OC(C(O)C2O)CO
CACTVS 3.341OC[CH]1O[CH]([CH](O)[CH]1O)N2C=CC(=O)CC2=O
CACTVS 3.341OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)CC2=O
FormulaC10 H13 N O6
Name1-((2R,3R,4S,5R)-TETRAHYDRO-3,4-DIHYDROXY-5-(HYDROXYMETHYL)FURAN-2-YL)PYRIDINE-2,4(1H,3H)-DIONE;
3-DEAZAURIDINE
ChEMBL
DrugBank
ZINC
PDB chain1zab Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1zab The 1.48 A Resolution Crystal Structure of the Homotetrameric Cytidine Deaminase from Mouse
Resolution2.36 Å
Binding residue
(original residue number in PDB)		V38 N54 E56 C65 E67
Binding residue
(residue number reindexed from 1)		V29 N45 E47 C56 E58
Annotation score2
Enzymatic activity
Enzyme Commision number 3.5.4.5: cytidine deaminase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0019239 deaminase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006248 CMP catabolic process
GO:0006249 dCMP catabolic process
GO:0009972 cytidine deamination
GO:0030308 negative regulation of cell growth
GO:0044206 UMP salvage
GO:0045980 negative regulation of nucleotide metabolic process
GO:0046898 response to cycloheximide
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0071217 cellular response to external biotic stimulus
GO:0072527 pyrimidine-containing compound metabolic process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1zab, PDBe:1zab, PDBj:1zab
PDBsum1zab
PubMed16784234
UniProtP56389|CDD_MOUSE Cytidine deaminase (Gene Name=Cda)

[Back to BioLiP]