Structure of PDB 1z6l Chain B Binding Site BS02

Receptor Information
>1z6l Chain B (length=484) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGR
KYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRV
DHDKELLLEIVDNEMSKFAELEFHSDCSFFQLVMKYLLQRRQFLTNDQIR
YLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSF
PQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSV
QPNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIV
TLANSTNEFVEIVRNAENLDELDSMLERTSVTCWSQPLFFVNLSKSTGVA
SFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVIDGMRP
ENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPVDMVVAMSNGQDSRIR
FAGEHTIMDGAGCAYGAWESGRREATRISDLLKL
Ligand information
Ligand IDDRE
InChIInChI=1S/C12H29N3/c13-9-5-1-3-7-11-15-12-8-4-2-6-10-14/h15H,1-14H2
InChIKeyMRNZSTMRDWRNNR-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		NCCCCCCNCCCCCCN
OpenEye OEToolkits 1.5.0C(CCCNCCCCCCN)CCN
FormulaC12 H29 N3
NameN-(6-AMINOHEXYL)HEXANE-1,6-DIAMINE;
BIS(HEXAMETHYLENE)TRIAMINE
ChEMBLCHEMBL318516
DrugBankDB04684
ZINCZINC000001598087
PDB chain1z6l Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1z6l crystal structure of Fms1 and its complex with spermine reveal substrate specificity
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H67 L173 W174 H175 D186 F189 L375 Y450 G487
Binding residue
(residue number reindexed from 1)		H60 L161 W162 H163 D174 F177 L355 Y429 G462
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H67
Catalytic site (residue number reindexed from 1) H60
Enzyme Commision number 1.5.3.17: non-specific polyamine oxidase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052897 N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052901 spermine oxidase activity
GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity
Biological Process
GO:0006338 chromatin remodeling
GO:0015940 pantothenate biosynthetic process
GO:0046208 spermine catabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1z6l, PDBe:1z6l, PDBj:1z6l
PDBsum1z6l
PubMed
UniProtP50264|FMS1_YEAST Polyamine oxidase FMS1 (Gene Name=FMS1)

[Back to BioLiP]