Structure of PDB 1wb9 Chain B Binding Site BS02

Receptor Information
>1wb9 Chain B (length=754) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQQYLRLKAQHPEILLFYRMGDFYTLFYDDAKRASQLLDISLTPMAGIPY
HAVENYLAKLVNQGESVAICERKVVRIVTPGTISDEALLQERQDNLLAAI
WQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAE
MSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCA
AGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGG
AENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTA
GLQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVD
SAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEW
RALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAP
INYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLL
PHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHP
VVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYI
GSYVPAQKVEIGPIDRIFTRVGTFMVEMTETANILHNATEYSLVLMDEIG
RGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVH
LDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLREL
ESIS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1wb9 Dual Role of Muts Glutamate 38 in DNA Mismatch Discrimination and in the Authorization of Repair.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		T462 K464 S478
Binding residue
(residue number reindexed from 1)		T426 K428 S442
Binding affinityPDBbind-CN: Kd=0.018uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0032136 adenine/cytosine mispair binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 DNA damage response
Cellular Component
GO:0005829 cytosol
GO:0032300 mismatch repair complex
GO:1990710 MutS complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1wb9, PDBe:1wb9, PDBj:1wb9
PDBsum1wb9
PubMed16407973
UniProtP23909|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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