Structure of PDB 1t3n Chain B Binding Site BS02

Receptor Information
>1t3n Chain B (length=388) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGN
YDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1t3n Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		L543 E547 K627 G663 K665 R763 Y775 G776 R777 E778 S779 R780 Q781 P783
Binding residue
(residue number reindexed from 1)		L97 E101 K181 G217 K219 R317 Y329 G330 R331 E332 S333 R334 Q335 P337
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1t3n, PDBe:1t3n, PDBj:1t3n
PDBsum1t3n
PubMed15254543
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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