Structure of PDB 1r64 Chain B Binding Site BS02

Receptor Information
>1r64 Chain B (length=481) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLPVKEAEDKLSINDPLFERQWHLVNPSFPGSDINVLDLWYNNITGAGVV
AAIVDDGLDYENEDLKDNFCAEGSWDFNDNTNLPKPRLSDDYHGTRCAGE
IAAKKGNNFCGVGVGYNAKISGIRILSGDITTEDEAASLIYGLDVNDIYS
CSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGD
NCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGEYIHS
SDINGRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVG
LEKNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYL
PTLYVSQSTNSTEETLESVITISEKSLQDANFKRIEHVTVTVDIDTEIRG
TTTVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGVGDWKI
KVKTTENGHRIDFHSWRLKLFGESIDSSKTE
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain1r64 Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1r64 Structural Basis for Differences in Substrate Selectivity in Kex2 and Furin Protein Convertases
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D431 K437
Binding residue
(residue number reindexed from 1)		D311 K317
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) D175 H213 N314 S385
Catalytic site (residue number reindexed from 1) D55 H93 N194 S265
Enzyme Commision number 3.4.21.61: kexin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1r64, PDBe:1r64, PDBj:1r64
PDBsum1r64
PubMed14992578
UniProtP13134|KEX2_YEAST Kexin (Gene Name=KEX2)

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