Structure of PDB 1p8x Chain B Binding Site BS02

Receptor Information
>1p8x Chain B (length=325) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHQGQIIYNW
QGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKP
MIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDA
FVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWE
ALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDL
ATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTP
ITVVKQGFEPPSFVGWFLGWDDDYW
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1p8x Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1p8x Activation in isolation: Exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin
Resolution2.0 Å
Binding residue
(original residue number in PDB)		N564 D565 E587
Binding residue
(residue number reindexed from 1)		N148 D149 E171
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:1p8x, PDBe:1p8x, PDBj:1p8x
PDBsum1p8x
PubMed14527664
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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