Structure of PDB 1p0y Chain B Binding Site BS02

Receptor Information
>1p0y Chain B (length=441) Species: 3888 (Pisum sativum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSLSPAVQTFWKWLQEEGVITAKTPVKASVVTEGLGLVALKDISRNDVIL
QVPKRLWINPDAVAASEIGRVCSELKPWLSVILFLIRERSREDSVWKHYF
GILPQETDSTIYWSEEELQELQGSQLLKTTVSVKEYVKNECLKLEQEIIL
PNKRLFPDPVTLDDFFWAFGILRSRAFSRLRNENLVVVPMADLINHSAGV
TTEDHAYEVKGAAGLFSWDYLFSLKSPLSVKAGEQVYIQYDLNKSNAELA
LDYGFIEPNENRHAYTLTLEISESDPFFDDKLDVAESNGFAQTAYFDIFY
NRTLPPGLLPYLRLVALGGTDAFLLESLFRDTIWGHLELSVSRDNEELLC
KAVREACKSALAGYHTTIEQDRELKEGNLDSRLAIAVGIREGEKMVLQQI
DGIFEQKELELDQLEYYQERRLKDLGLCGENGDILENLYFQ
Ligand information
Ligand IDMLZ
InChIInChI=1S/C7H16N2O2/c1-9-5-3-2-4-6(8)7(10)11/h6,9H,2-5,8H2,1H3,(H,10,11)/t6-/m0/s1
InChIKeyPQNASZJZHFPQLE-LURJTMIESA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CNCCCCC(C(=O)O)N
OpenEye OEToolkits 1.5.0CNCCCC[C@@H](C(=O)O)N
CACTVS 3.341CNCCCC[CH](N)C(O)=O
CACTVS 3.341CNCCCC[C@H](N)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCCCNC
FormulaC7 H16 N2 O2
NameN-METHYL-LYSINE
ChEMBL
DrugBankDB01714
ZINCZINC000001529511
PDB chain1p0y Chain C Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1p0y Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT
Resolution2.55 Å
Binding residue
(original residue number in PDB)		R222 F224 S225 R226 Y287
Binding residue
(residue number reindexed from 1)		R175 F177 S178 R179 Y240
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y287
Catalytic site (residue number reindexed from 1) Y240
Enzyme Commision number 2.1.1.127: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase.
2.1.1.259: [fructose-bisphosphate aldolase]-lysine N-methyltransferase.
Gene Ontology
Molecular Function
GO:0016279 protein-lysine N-methyltransferase activity
GO:0030785 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
Biological Process
GO:0018022 peptidyl-lysine methylation
Cellular Component
GO:0009507 chloroplast

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1p0y, PDBe:1p0y, PDBj:1p0y
PDBsum1p0y
PubMed12819771
UniProtQ43088|RBCMT_PEA Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic (Gene Name=RBCMT)

[Back to BioLiP]