Structure of PDB 1ord Chain B Binding Site BS02

Receptor Information
>1ord Chain B (length=730) Species: 1593 (Lactobacillus sp. 30A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSLKIASTQEARQYFDTDRVVVDAVGSDFTDVGAVIAMDYETDVIDAAD
ATKFGIPVFAVTKDAQAISADELKKIFHIIDLENKFDATVNAREIETAVN
NYEDSILPPFFKSLKEYVSRGLIQFDCPGHQGGQYYRKHPAGREFYDFFG
ETVFRADLCNADVALGDLLIHEGPAVAAEKHAARVYNADKTYFVLGGSSN
ANNTVTSALVSNGDLVLFDRNNHKSVYNSALAMAGGRPVYLQTNRNPYGF
IGGIYDSDFDEKKIRELAAKVDPERAKWKRPFRLAVIQLGTYDGTIYNAH
EVVKRIGHLCDYIEFDSAWVGYEQFIPMMRNSSPLLIDDLGPEDPGIIVV
QSVHKQQAGFSQTSQIHKKDSHIKGQLRYCDHKHFNNSFNLFMSTSPFYP
MYAALDVNAAMQEGEAGRKLWHDLLITTIEARKKLIKAGSMFRPFVPPVV
NGKKWEDGDTEDMANNIDYWRFEKGAKWHAYEGYGDNQYYVDPNKFMLTT
PGINPETGDYEDFGVPATIVANYLRDHGIIPEKSDLNSILFLMTPAETPA
KMNNLITQLLQLQRLIEEDAPLKQVLPSIYAANEERYNGYTIRELCQELH
DFYKNNNTFTYQKRLFLREFFPEQGMLPYEARQEFIRNHNKLVPLNKIEG
EIALEGALPYPPGVFCVAPGEKWSETAVKYFTILQDGINNFPGFAPEIQG
VYFKQEGDKVVAYGEVYDAEVAKNDDRYNN
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1ord Chain B Residue 731 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ord Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G197 S198 S199 H223 D316 A318 W319 S352 H354 K355
Binding residue
(residue number reindexed from 1)		G197 S198 S199 H223 D316 A318 W319 S352 H354 K355
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H223 D316 K355
Catalytic site (residue number reindexed from 1) H223 D316 K355
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 amino acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ord, PDBe:1ord, PDBj:1ord
PDBsum1ord
PubMed7563080
UniProtP43099|DCOR_LACS3 Inducible ornithine decarboxylase (Gene Name=odcI)

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