Structure of PDB 1ocr Chain B Binding Site BS02

Receptor Information

>1ocr Chain B (length=227) Species: 9913 (Bos taurus)

MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKL
THTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTM
GHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTI
RMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSSRPGLYYGQCSEIC
GSNHSFMPIVLELVPLKYFEKWSASML

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 1ocr Chain B Residue 229

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ocr Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase.
• Resolution: 2.35 Å
• Binding residue (original residue number in PDB): C196 E198 C200 H204
• Binding residue (residue number reindexed from 1): C196 E198 C200 H204
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0022900 electron transport chain
• GO:0042773 ATP synthesis coupled electron transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0045277 respiratory chain complex IV

External links

• PDB: RCSB:1ocr, PDBe:1ocr, PDBj:1ocr
• PDBsum: 1ocr
• PubMed: 9624044
• UniProt: P68530|COX2_BOVIN Cytochrome c oxidase subunit 2 (Gene Name=MT-CO2)