Structure of PDB 1n4m Chain B Binding Site BS02

Receptor Information
>1n4m Chain B (length=338) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEK
FAKAVGAGCVAIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLND
NIFHMSLLACALEVVMATYSRSTTDLSFPWILNVLNLKAFDFYKVIESFI
KAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKTREGKSTSL
SLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRD
RHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEE
EYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1n4m Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Y709 K713 V714 N716 Y756 N757 M761 K765 A772 S773 R775
Binding residue
(residue number reindexed from 1)		Y262 K266 V267 N269 Y309 N310 M314 K318 A325 S326 R328
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1n4m, PDBe:1n4m, PDBj:1n4m
PDBsum1n4m
PubMed12502741
UniProtP06400|RB_HUMAN Retinoblastoma-associated protein (Gene Name=RB1)

[Back to BioLiP]