Structure of PDB 1mu9 Chain B Binding Site BS02

Receptor Information
>1mu9 Chain B (length=434) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDV
DWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIA
FGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADG
THKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGST
PGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADE
SKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTA
EKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANL
SKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFMATFPVPY
DLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain1mu9 Chain B Residue 610 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1mu9 Insights Into Substrate Binding and Catalytic Mechanism of Human Tyrosyl-DNA Phosphodiesterase (Tdp1) from Vanadate- and Tungstate-Inhibited Structures
Resolution2.05 Å
Binding residue
(original residue number in PDB)		H263 H493
Binding residue
(residue number reindexed from 1)		H105 H326
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1mu9, PDBe:1mu9, PDBj:1mu9
PDBsum1mu9
PubMed12470949
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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