Structure of PDB 1lcn Chain B Binding Site BS02

Receptor Information

>1lcn Chain B (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

Ligand information

• Ligand ID: SCN
• InChI: InChI=1S/CHNS/c2-1-3/h3H/p-1
• InChIKey: ZMZDMBWJUHKJPS-UHFFFAOYSA-M
• SMILES:
  OpenEye OEToolkits 1.5.0: C(#N)[S-]
  ACDLabs 10.04
  CACTVS 3.341: [S-]C#N
• Formula: C N S
• Name: THIOCYANATE ION
• PDB chain: 1lcn Chain B Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1lcn Structural effects of monovalent anions on polymorphic lysozyme crystals.
• Resolution: 1.63 Å
• Binding residue (original residue number in PDB): Y53 D66 S81
• Binding residue (residue number reindexed from 1): Y53 D66 S81
• Annotation score: 3

Enzymatic activity

• Catalytic site (original residue number in PDB): E35 N46 D48 S50 D52 N59
• Catalytic site (residue number reindexed from 1): E35 N46 D48 S50 D52 N59
• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:1lcn, PDBe:1lcn, PDBj:1lcn
• PDBsum: 1lcn
• PubMed: 11418760
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)