Structure of PDB 1jm7 Chain B Binding Site BS02

Receptor Information
>1jm7 Chain B (length=97) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCV
SDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1jm7 Chain B Residue 144 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1jm7 Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
ResolutionN/A
Binding residue
(original residue number in PDB)		H68 C83 C86
Binding residue
(residue number reindexed from 1)		H43 C58 C61
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006301 postreplication repair
GO:0006513 protein monoubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:1jm7, PDBe:1jm7, PDBj:1jm7
PDBsum1jm7
PubMed11573085
UniProtQ99728|BARD1_HUMAN BRCA1-associated RING domain protein 1 (Gene Name=BARD1)

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