Structure of PDB 1gng Chain B Binding Site BS02

Receptor Information

>1gng Chain B (length=356) Species: 9606 (Homo sapiens)

VSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCD
SGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVY
LNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGI
CHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL
IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT
REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA
RLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATIL
IPPHAR

Ligand information

>1gng Chain Y (length=25) Species: 9606 (Homo sapiens)

DPHRLLQQLVLSGNLIKEAVRRLHS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1gng The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): F229 V263 L266 K271 Y288 E290 K292 F293 P294 I296
• Binding residue (residue number reindexed from 1): F202 V236 L239 K244 Y261 E263 K265 F266 P267 I269

Enzymatic activity

• Catalytic site (original residue number in PDB): D181 K183 N186 D200 S219
• Catalytic site (residue number reindexed from 1): D154 K156 N159 D173 S192
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.11.26: [tau protein] kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:1gng, PDBe:1gng, PDBj:1gng
• PDBsum: 1gng
• PubMed: 11738041
• UniProt: P49841|GSK3B_HUMAN Glycogen synthase kinase-3 beta (Gene Name=GSK3B)