Structure of PDB 1fsi Chain B Binding Site BS02

Receptor Information
>1fsi Chain B (length=170) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEEVKKDVYSVWALPDEESEPRFKKLMEALRSEFTGPRFVPHVTVAVSAY
LTADEAKKMFESACDGLKAYTATVDRVSTGTFFFQCVFLLLQTTPEVMEA
GETPYMPHLSLLYAELTEEEKKNAQEKAYTLDSSLDGLSFRLNRLALCKT
DTEDKTLETWETVAVCNLNP
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1fsi Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1fsi Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R76 S78 T79 Q136
Binding residue
(residue number reindexed from 1)		R76 S78 T79 Q125
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H42 T44 M117 H119 S121 Y124
Catalytic site (residue number reindexed from 1) H42 T44 M106 H108 S110 Y113
Enzyme Commision number 3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase.
Gene Ontology
Molecular Function
GO:0004112 cyclic-nucleotide phosphodiesterase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1fsi, PDBe:1fsi, PDBj:1fsi
PDBsum1fsi
PubMed11080166
UniProtO04147|CPD_ARATH Cyclic phosphodiesterase (Gene Name=At4g18930)

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