Structure of PDB 1ep3 Chain B Binding Site BS02

Receptor Information
>1ep3 Chain B (length=261) Species: 1358 (Lactococcus lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQLQEMMTVVSQREVAYNIFEMVLKGTLVDEMDLPGQFLHLAVPNGAMLL
RRPISISSWDKRAKTCTILYRIGDETTGTYKLSKLESGAKVDVMGPLGNG
FPVAEVTSTDKILIIGGGIGVPPLYELAKQLEKTGCQMTILLGFASENVK
ILENEFSNLKNVTLKIATDDGSYGTKGHVGMLMNEIDFEVDALYTCGAPA
MLKAVAKKYDQLERLYISMESRMACGIGACYACVEHDKEDESHALKVCED
GPVFLGKQLSL
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain1ep3 Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ep3 Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		M224 C226 G227 G229 C231 Y232 C234 C249
Binding residue
(residue number reindexed from 1)		M223 C225 G226 G228 C230 Y231 C233 C248
Annotation score4
Enzymatic activity
Enzyme Commision number 1.3.3.1: Transferred entry: 1.3.98.1.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ep3, PDBe:1ep3, PDBj:1ep3
PDBsum1ep3
PubMed11188687
UniProtP56968|PYRK_LACLM Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit (Gene Name=pyrK)

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