Structure of PDB 1edh Chain B Binding Site BS02

Receptor Information
>1edh Chain B (length=211) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFI
IERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQN
DNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVS
QDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLS
TTAKAVITVKD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1edh Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1edh Structural basis of calcium-induced E-cadherin rigidification and dimerization.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E11 E69 D100 Q101 D103 D136
Binding residue
(residue number reindexed from 1)		E9 E67 D98 Q99 D101 D134
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1edh, PDBe:1edh, PDBj:1edh
PDBsum1edh
PubMed8598933
UniProtP09803|CADH1_MOUSE Cadherin-1 (Gene Name=Cdh1)

[Back to BioLiP]