Structure of PDB 1dqn Chain B Binding Site BS02

Receptor Information

>1dqn Chain B (length=230) Species: 5741 (Giardia intestinalis)

MICSVTGKPVKDVLSTFFKDRNDVLESEVKKFHLLATFEECKALAADTAR
RMNEYYKDVAEPVTLVALLTGAYLYASLLTVHLTFPYTLHFVKVSSYKGT
RQESVVFDEEDLKQLKEKREVVLIDEYVDSGHTIFSIQEQIKHAKICSCF
VKDVDAIKKHSALADTKMFYGYTPMPKGSWLIGFGLDDNGLRRGWAHLFD
INLSESEVTEFRRRLTEHIKGLNINGVNRY

Ligand information

• Ligand ID: POP
• InChI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-2
• InChIKey: XPPKVPWEQAFLFU-UHFFFAOYSA-L
• SMILES:
  OpenEye OEToolkits 1.5.0: O[P@@](=O)([O-])O[P@@](=O)(O)[O-]
  CACTVS 3.341: O[P]([O-])(=O)O[P](O)([O-])=O
  ACDLabs 10.04: [O-]P(=O)(O)OP([O-])(=O)O
  OpenEye OEToolkits 1.5.0: OP(=O)([O-])OP(=O)(O)[O-]
• Formula: H2 O7 P2
• Name: PYROPHOSPHATE 2-
• PDB chain: 1dqn Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1dqn Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
• Resolution: 1.75 Å
• Binding residue (original residue number in PDB): L69 T70 G71 R193
• Binding residue (residue number reindexed from 1): L69 T70 G71 R193
• Annotation score: 5

Enzymatic activity

• Enzyme Commision number: 2.4.2.8: hypoxanthine phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0004422 hypoxanthine phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006178 guanine salvage
• GO:0032263 GMP salvage
• GO:0032264 IMP salvage
• GO:0046100 hypoxanthine metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1dqn, PDBe:1dqn, PDBj:1dqn
• PDBsum: 1dqn
• PubMed: 10841757
• UniProt: Q24973