Structure of PDB 1dew Chain B Binding Site BS02

Receptor Information
>1dew Chain B (length=279) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGPALYEDPPDHKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAP
DILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCP
LKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWD
EAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQG
FGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSH
SLLPALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
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PDB1dew DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
Resolution2.65 Å
Binding residue
(original residue number in PDB)		D70 G71 R73 A74 K78 E126 Y269 M271
Binding residue
(residue number reindexed from 1)		D31 G32 R34 A35 K39 E87 Y230 M232
Enzymatic activity
Catalytic site (original residue number in PDB) D70 E96 N212 D283 D308
Catalytic site (residue number reindexed from 1) D31 E57 N173 D244 D269
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1dew, PDBe:1dew, PDBj:1dew
PDBsum1dew
PubMed10667800
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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