Structure of PDB 1d3t Chain B Binding Site BS02
Receptor Information
>1d3t Chain B (length=250) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
>1d3t Chain H (length=12) Species:
6421
(Hirudo medicinalis) [
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GDFEEIPEEYLQ
Receptor-Ligand Complex Structure
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PDB
1d3t
The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
F55 Q60 L62 L96 T105 R106 Y107 K113 I114
Binding residue
(residue number reindexed from 1)
F19 Q24 L26 L60 T69 R70 Y71 K77 I78
Enzymatic activity
Catalytic site (original residue number in PDB)
H79 D135 E238 G239 D240 S241 G242
Catalytic site (residue number reindexed from 1)
H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1d3t
,
PDBe:1d3t
,
PDBj:1d3t
PDBsum
1d3t
PubMed
10739244
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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