Structure of PDB 1csm Chain B Binding Site BS02

Receptor Information
>1csm Chain B (length=252) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDFTKPETVLNLQNIRDELVRMEDSIIFKFIERSHFATCPSVYEANHPGL
EIPNFKGSFLDWALSNLEIAHSRIRRFESPDETPFFPDKIQKSFLPSINY
PQILAPYAPEVNYNDKIKKVYIEKIIPLISKRDGDDKNNFGSVATRDIEC
LQSLSRRIHFGKFVAEAKFQSDIPLYTKLIKSKDVEGIMKNITNSAVEEK
ILERLTKKAEVYGVDPTERRIIPEYLVKIYKEIVIPITKEVEVEYLLRRL
EE
Ligand information
Ligand IDTRP
InChIInChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
InChIKeyQIVBCDIJIAJPQS-VIFPVBQESA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc2c1ccccc1nc2
OpenEye OEToolkits 1.5.0c1ccc2c(c1)c(c[nH]2)C[C@@H](C(=O)O)N
OpenEye OEToolkits 1.5.0c1ccc2c(c1)c(c[nH]2)CC(C(=O)O)N
CACTVS 3.341N[CH](Cc1c[nH]c2ccccc12)C(O)=O
CACTVS 3.341N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
FormulaC11 H12 N2 O2
NameTRYPTOPHAN
ChEMBLCHEMBL54976
DrugBankDB00150
ZINCZINC000000083315
PDB chain1csm Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1csm The crystal structure of allosteric chorismate mutase at 2.2-A resolution.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		N138 N139 G141 S142
Binding residue
(residue number reindexed from 1)		N138 N139 G141 S142
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) R16 R157 K168 N194 E198 T242 E246
Catalytic site (residue number reindexed from 1) R16 R157 K168 N194 E198 T238 E242
Enzyme Commision number 5.4.99.5: chorismate mutase.
Gene Ontology
Molecular Function
GO:0004106 chorismate mutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0072545 L-tyrosine binding
GO:0120284 tryptophan binding
Biological Process
GO:0006571 tyrosine biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0046417 chorismate metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1csm, PDBe:1csm, PDBj:1csm
PDBsum1csm
PubMed7971967
UniProtP32178|CHMU_YEAST Chorismate mutase (Gene Name=ARO7)

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