Structure of PDB 1cdk Chain B Binding Site BS02
Receptor Information
>1cdk Chain B (length=343) Species:
9823
(Sus scrofa) [
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KGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRV
MLVKHKETGNHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE
YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL
HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAP
EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRF
PSHFSSDLKDLLRNLLQVDLTKRFGNLKDGVNDIKNHKWFATTDWIAIYQ
RKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
1cdk Chain B Residue 401 [
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Receptor-Ligand Complex Structure
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PDB
1cdk
Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
N171 D184
Binding residue
(residue number reindexed from 1)
N164 D177
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
N171 D184
Catalytic site (residue number reindexed from 1)
N164 D177
Enzyme Commision number
2.7.11.11
: cAMP-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0004679
AMP-activated protein kinase activity
GO:0004691
cAMP-dependent protein kinase activity
GO:0005524
ATP binding
GO:0034237
protein kinase A regulatory subunit binding
GO:0106310
protein serine kinase activity
Biological Process
GO:0006468
protein phosphorylation
GO:0010737
protein kinase A signaling
GO:0016310
phosphorylation
GO:0034605
cellular response to heat
GO:1904145
negative regulation of meiotic cell cycle process involved in oocyte maturation
GO:1904262
negative regulation of TORC1 signaling
Cellular Component
GO:0001669
acrosomal vesicle
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0005952
cAMP-dependent protein kinase complex
GO:0036126
sperm flagellum
GO:0042585
germinal vesicle
GO:0048471
perinuclear region of cytoplasm
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1cdk
,
PDBe:1cdk
,
PDBj:1cdk
PDBsum
1cdk
PubMed
8384554
UniProt
P36887
|KAPCA_PIG cAMP-dependent protein kinase catalytic subunit alpha (Gene Name=PRKACA)
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