Structure of PDB 1ca8 Chain B Binding Site BS02
Receptor Information
>1ca8 Chain B (length=249) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKPQELLCGASLISDRWVLTAAHCLLYPPWD
KNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIA
LMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETQPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
>1ca8 Chain C (length=8) Species:
6421
(Hirudo medicinalis) [
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FEEIPEEY
Receptor-Ligand Complex Structure
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PDB
1ca8
Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
F34 R67 R73 T74 R75 Y76 K81 I82
Binding residue
(residue number reindexed from 1)
F19 R61 R67 T68 R69 Y70 K76 I77
Enzymatic activity
Catalytic site (original residue number in PDB)
H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)
H42 D98 E193 G194 D195 S196 G197
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1ca8
,
PDBe:1ca8
,
PDBj:1ca8
PDBsum
1ca8
PubMed
9724521
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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