Structure of PDB 6p5k Chain Aj Binding Site BS02

Receptor Information

>6p5k Chain Aj (length=86) Species: 9986 (Oryctolagus cuniculus)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

Ligand information

>6p5k Chain 8 (length=151)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaac
gcacuugcggccccggguuccucccggggcuacgccugucugagcgucgc
u

.........................................<<<<<<.<<
.....>>>.....(.<<<......>>........>>>..)...>>>....
<<<..>>><<<<<<<<.......>>>>>>>>...................
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6p5k The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): R20 R21 C22 G23 Y39 K42 N57 T58 T59 T61 G62 R63 M64 R65 H66 L67 K68 V70 Y71 R72 F74 H76 R79 E80 T82 P84 K85 P86 K87
• Binding residue (residue number reindexed from 1): R19 R20 C21 G22 Y38 K41 N56 T57 T58 T60 G61 R62 M63 R64 H65 L66 K67 V69 Y70 R71 F73 H75 R78 E79 T81 P83 K84 P85 K86

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6p5k, PDBe:6p5k, PDBj:6p5k
• PDBsum: 6p5k
• PubMed: 31609474
• UniProt: U3KPD5|RL37_RABIT Large ribosomal subunit protein eL37 (Gene Name=RPL37)