Structure of PDB 6p5j Chain Aj Binding Site BS02

Receptor Information

>6p5j Chain Aj (length=86) Species: 9986 (Oryctolagus cuniculus)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

Ligand information

>6p5j Chain 8 (length=151)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaac
gcacuugcggccccggguuccucccggggcuacgccugucugagcgucgc
u

.........................................<<<<<<.<<
.....>>>.....(.<<<......>>........>>>..)...>>>....
<<<..>>><<<<<<<<.......>>>>>>>>...................
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6p5j The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): R20 R21 C22 G23 K42 N57 T59 G62 R63 M64 R65 H66 L67 K68 V70 R72 F74 H76 F78 R79 E80 G81 T82 P84 K87
• Binding residue (residue number reindexed from 1): R19 R20 C21 G22 K41 N56 T58 G61 R62 M63 R64 H65 L66 K67 V69 R71 F73 H75 F77 R78 E79 G80 T81 P83 K86

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6p5j, PDBe:6p5j, PDBj:6p5j
• PDBsum: 6p5j
• PubMed: 31609474
• UniProt: U3KPD5|RL37_RABIT Large ribosomal subunit protein eL37 (Gene Name=RPL37)