Structure of PDB 8cdr Chain Aa Binding Site BS02

Receptor Information
>8cdr Chain Aa (length=816) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGKSTAIS
LYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGAL
VVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQ
TFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFA
TRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMF
ILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMRK
FLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKA
DLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDL
FIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAH
NMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESG
EHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTAL
SKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADDYGWD
VTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQWATKEGPI
FGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQE
PVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNE
SFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRH
GMKEEVPGWQEYYDKL
Ligand information
>8cdr Chain Bb (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccu
guguucgauccacagaauucgcacca
<<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<
<<.........>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB8cdr mRNA reading frame maintenance during eukaryotic ribosome translocation
Resolution2.04 Å
Binding residue
(original residue number in PDB)		K578 H583 R585 H694 D696 X699 L842
Binding residue
(residue number reindexed from 1)		K552 H557 R559 H668 D670 X673 L816
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019843 rRNA binding
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0045901 positive regulation of translational elongation
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cdr, PDBe:8cdr, PDBj:8cdr
PDBsum8cdr
PubMed38030725
UniProtP32324|EF2_YEAST Elongation factor 2 (Gene Name=EFT1)

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