Structure of PDB 4v7p Chain AV Binding Site BS02

Receptor Information

>4v7p Chain AV (length=354) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MLDKLDRLEEEYRELEALLSDPEVLKDKGRYQSLSRRYAEMGEVIGLIRE
YRKVLEDLEQAESLLDDPELKEMAKAEREALLARKEALEKELERHLLPKD
PMDERDAIVEIRAGTGGEEAALFARDLFNMYLRFAEEMGFETEVLDSHPT
DLGGFSKVVFEVRGPGAYGTFKYESGVHRVQRVPVTETQGRIHTSTATVA
VLPKAEEEDFALNMDEIRIDVMRASGPGGQGVNTTDSAVRVVHLPTGIMV
TCQDSRSQIKNREKALMILRSRLLEMKRAEEAERLRKTRLAQIGTGERSE
KIRTYNFPQSRVTDHRIGFTTHDLEGVLSGHLTPILEALKRADQERQLAA
LAEG

Ligand information

>4v7p Chain AW (length=77) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucg
ucgguucaaauccggcccccgcaacca

.<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<
<<<<.......>>>>>>>>>>>.....

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4v7p Recognition of the amber UAG stop codon by release factor RF1.
Resolution	3.62 Å
Binding residue (original residue number in PDB)	D151 G228 G229 Q230 R256
Binding residue (residue number reindexed from 1)	D151 G228 G229 Q230 R256

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003747	translation release factor activity
GO:0016149	translation release factor activity, codon specific

	Biological Process
GO:0006412	translation
GO:0006415	translational termination

	Cellular Component
GO:0005737	cytoplasm

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4v7p, PDBe:4v7p, PDBj:4v7p
PDBsum	4v7p
PubMed	20588254
UniProt	Q72HB8\|RF1_THET2 Peptide chain release factor 1 (Gene Name=prfA)

[Back to BioLiP]