Structure of PDB 4v4b Chain AT Binding Site BS02

Receptor Information
>4v4b Chain AT (length=819) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAGITI
KSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALR
VTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVS
KEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAF
TIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLE
RAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALL
KVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIK
NCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVP
GKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLT
TSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLT
YMSESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESE
SSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIMA
DDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQWA
TKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLA
DPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQTPLFTVKAYLP
VNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAAR
KRHGMKEEVPGWQEYYDKL
Ligand information
>4v4b Chain B3 (length=2863) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugcca
agcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuu
ccgaaugagaaucucuacaauugcuucgcgcaaugaggaaccccgagaac
ugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguua
guaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaa
uguggugucagggcuaccucucaucagccgaccgucucgacgaagucucu
uggaacagagcgugauacagggugacaaccccguacucgagaccaguacg
acgugcgguagugccagaguagcggggguuggauaucccucgcgaauaac
gcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaaca
aguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauag
agcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucga
cgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguu
cugucguacguuuugaaaaacgagccagggagugugucugcauggcaagu
cuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggc
uugcccgagggccgccgucuucaagggcggggagccauguggacacgacc
cgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcac
guggaagucuguuagaguugguguccuacaauacccucucgugaucuaug
uguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaa
acaugucgaagcaugaccuccgccgagguagucugugagguagagcgacc
gauuggucuagggggcccaccagccuaccaaaccugucaaacuccaaacu
uacagacgccguuugacgcggggauuccggugcgcgggguaagccugugu
accaggaggggaacaacccagagauagguuaagguccccaaguguggauu
aaguguaauccucugaagguggucucgagcccuagacagccgggauguug
gcuuagaagcagccaucauuuaaagagugcguaacagcucaccggccgag
guuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccugu
ccguaccacucauacugguaaucgaguagauuggcgcucuaauuggaugg
aaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggcc
auaguagcagcgauagucgggugagaaccccgacggccuaauggauaagg
guuccucagcacugcugaucagcugaggguuagccgguccuaagucauac
cgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccac
uaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgccca
gucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaac
ggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagca
uaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaa
ggccugucgggagcaaccaacguuagggaauucggcaaguuagucccgua
ccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacu
cggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaag
gacucguacggucacugaauccugcccagugcagguaucugaacaccucg
uacaagaggacgaaggaccugucaacggcggccguaacuauaacgguccu
aagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauu
aaccagagcuucacugucccaacguugggcccggugaacuguacauucca
gugcggagucuggagacacccagggggaagcgaagacccuauggagcuuu
acugcaggcugucgcugagucuuggucggggaugcguaggauagguggga
gcgcaagcgccggugaaauaccacccuuccccggcugggacucucacucc
gggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcuc
gaaaagauaucgagcgcgcccuauggcuaucucagccgggacggagaccc
ggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacga
ggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugau
gcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucac
ucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucc
cuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauu
aaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcu
aucuacuggguguguggugucugacaagaacgaccguauaguacgagagg
aacuacgguugguggccacugguguaccgguuguucgagagagcacgugc
cggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaa
cccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucg
auagacucggggugugcgcgucgagguaacgagacguuaagcccacgagc
acuaacagaccaa
..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((.
.((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>
>>....<<<...>>>....<<<<<.....>>>>>.>>...<<<<<<....
.<......>......>>>>>.>.........<<.....>>...<<<<<..
...<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>..
...>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<
......>>>>.((......<<<.....))>>>....>>>>>>>......>
..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<
<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...........
....<<....>>....))..........<<<.....>>>...........
........>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<
.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>
>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<
<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<
..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<
.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>
>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>
>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<...
.<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....
<<..<<.....<<<<<......>>>..>>...>>..>>...>>.>...>>
>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>
>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.
....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<
<<<.......>>>>...>>.........<<......>>...>>>>>...>
>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>
><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<....
..<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><
<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<
...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.
<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<
<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<...>>>>>
>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....
>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>
>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>
>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...
..<..>......>>>>><<<<<<<<<.....>>>>>>>>>..........
..<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>
>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<.
.....>>>>.....>>>>>>>>..>>>>>.<<<...........>>>...
..<...............<<<<<.......>>>>>.....>....>>>>>
..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<
<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..
<<<<<.<<<<<<<<.....<.<.<<.<<<<<<...........<<<<<..
<<....>>............>>>>>..>>>>>>.>>>..>......<<<<
....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<
...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>
>>>.....<<...(((>>.....>>>>>>...<<<<<<<<<.........
>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>
>>>>>>>>>>>..........>>>>..]]>>>>........<<<.<.<<<
<<<...<<.......>>...>>>>>>...>>>>.........<<<<<.<<
<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>...
...>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]].
.))).>>>>>>>...<<<<<<...<<<<..<<<<<<<<............
...>>>>>>>><<<<<...<<<<...<<<<<<<<<<....>>>>>...>>
>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....
>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>...
.<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>.
.>>>...>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v4b Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.
Resolution11.7 Å
Binding residue
(original residue number in PDB)
H27 D29 V109 D110 E133 V137 Q138 E535 L536 E539 E737 Q738 G741 Y744 S745 N748 K749 S756 E757 R785
Binding residue
(residue number reindexed from 1)
H25 D27 V89 D90 E113 V117 Q118 E515 L516 E519 E717 Q718 G721 Y724 S725 N728 K729 S736 E737 R762
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019843 rRNA binding
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0045901 positive regulation of translational elongation
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4v4b, PDBe:4v4b, PDBj:4v4b
PDBsum4v4b
PubMed14976550
UniProtP32324|EF2_YEAST Elongation factor 2 (Gene Name=EFT1)

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