Structure of PDB 8wq2 Chain AS2P Binding Site BS02

Receptor Information

>8wq2 Chain AS2P (length=196) Species: 330779 (Sulfolobus acidocaldarius DSM 639)

ELLVPLDTYLSAGVHIGTHTCTRYMERFIYRVRPEGLYVLDVRKIDERLR
VAAKFISRFRPEAVLTVASRPYAFTPVQKFSEVVRGKEISGRFPPGTLTN
PYLDNYIEPEVLIVTDPRTDLQAIKEASKVGIPIVAFTDTDARVDFIDVI
IPANNKGRKSLALLYWVLARQILRERKEIPLDGDIPLRVEDFETRL

Ligand information

• Ligand ID: UNK
• InChI: InChI=1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
• InChIKey: QWCKQJZIFLGMSD-VKHMYHEASA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: CCC(C(=O)O)N
  OpenEye OEToolkits 1.5.0: CC[C@@H](C(=O)O)N
  CACTVS 3.341: CC[C@H](N)C(O)=O
  CACTVS 3.341: CC[CH](N)C(O)=O
  ACDLabs 10.04: O=C(O)C(N)CC
• Formula: C4 H9 N O2
• Name: UNKNOWN
• ChEMBL: CHEMBL1230782
• ZINC: ZINC000000901351
• PDB chain: 8wq2 Chain AS2P Residue 306

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8wq2 Structural basis of translation inhibition by a valine tRNA-derived fragment
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): K81 R85
• Binding residue (residue number reindexed from 1): K54 R58
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit

External links

• PDB: RCSB:8wq2, PDBe:8wq2, PDBj:8wq2
• PDBsum: 8wq2
• PubMed: 38599770
• UniProt: P39478|RS2_SULAC Small ribosomal subunit protein uS2 (Gene Name=rps2)